Clinical Research and Trials
Clinical Trials by Condition
Please find trials at MNRH listed by the following conditions:
Stem Cell Study
Purpose: This study will evaluate the clinical effectiveness of the SB623 Modified Stem Cell on motor outcomes of stroke survivors with ischemic-type lesions. To learn more
Upper Extremity Studies
Purpose: There is rodent evidence for timing effects in rehabilitation; motor training delivered at certain times may be more effective. If analogous critical periods can be identified after human stroke, then existing clinical resources can be better utilized to promote recovery. To learn more
Purpose: This study is interested in determining whether different shoulder positions or muscle activations influence the brain’s control over hand muscles differently in individuals who have suffered a stroke compared to healthy individuals. In addition, the study will assist investigators understand why certain atypical movement patterns appear in individuals with stroke. To learn more
A Phase 2a, Randomized, Double-Blind, Placebo-Controlled 21 Day Treatment Study, Including an fMRI Sub-study, to Evaluate the Effect of HT-3951 on Upper Extremity Motor Function Following Ischemic Stroke
Purpose: This outpatient study that will utilize standard stroke rehabilitation outcome measures to evaluate the effect of the monoamine oxidase Type B (MAO-B) inhibitor, HT-3951, on motor recovery and behavior in medically stable subjects following ischemic stroke. To learn more
Purpose: This trial involves a painless, non-invasive, investigational test of brain function called transcranial magnetic stimulation (TMS). To learn moreHand Exoskeleton Rehabilitation Robot (HEXORR)
Purpose: Evaluate the effectiveness of the HEXORR device in remediating motor impairment of the hand in chronic stroke survivors. To learn more
Purpose: HandSOME is a lightweight wearable hand orthosis that increases range of motion and decreases effort during grasping tasks. The goal of this study is to evaluate the HandSOME device’s effectiveness in the rehabilitation of stroke patients through an 8-week intervention. To learn more
Purpose: The goal of this study is to develop a biomimetic hand exoskeleton device that enables functional movements of the hand for stroke survivors. In addition, the study is interested in assessing the efficacy of a ‘subject-specific’ training that provides ‘targeted assistance’ to the impaired muscle-tendons of stroke survivors. To learn more
Purpose: The goal of the project is to develop a robotic device capable of treating upper-extremity movement impairments resulting from stroke. The developed device will assist in the training of tasks involving reach and grasp of physical objects requiring varying grasp patterns. To learn more
Purpose: This longitudinal observational study seeks to identify molecular markers of brain repair in the blood that signal why some stroke patients have good recovery of arm function while others have poor recovery. To learn more
Cognition After Stroke Studies
Purpose: This study uses cognitive testing, functional MRI, and disability assessments to investigate how brain function and organization are altered by right-hemisphere stroke, and how these changes relate to long-term recovery. To learn more
Purpose: These studies focus on understanding the varying neurological mechanisms associated with brain plasticity after stroke and its impact on speech recovery. To learn more
PORSCHE – A Prospective multi-center study comparing the performance if the dysphasia detection system (DDS) in detecting impaired Swallowing safety and efficiency as Compared to the clinical reference method – videofluorosopic swallowing study (VFSS)
Purpose: To show whether a new investigational device is safe and works for identifying swallowing impairment. To learn more.
Spinal Cord Injury
Development of a Urinary Symptoms Questionnaire People with Neuropathic Bladder – VoidingPurpose: To develop an instrument, the Urinary Symptom Questionnaire for individuals with neurogenic bladder due to spinal cord injury (SCI) or Multiple Sclerosis (MS) but can void spontaneously. We will then explore the use of that instrument to enhance the diagnostic approach to urinary tract infection (UTI) in this population. To learn moreDevelopment of a Urinary Symptoms Questionnaire People with Neuropathic Bladder – Indwelling Catheters
Purpose: To develop an instrument, the Urinary Symptom Questionnaire for individuals with neurogenic bladder due to spinal cord injury (SCI) who utilize indwelling urethral or suprapubic catheters (IUSC) and then explore the use of that instrument to enhance the diagnostic approach to urinary tract infection (UTI) in this population. To learn more
Traumatic Brain Injury
Title: A double-blind, randomized, sham-controlled study of the safety and effectiveness of the Portable Neuromodulation Stimulator (PoNS™) 4.0 device for cranial nerve noninvasive neuromodulation (CN-NINM) training in subjects with a chronic balance deficit due to mild-to-moderate traumatic brain injury (TBI)
Sponsor: NeuroHabilitation, Inc.
PI: Yochelson, Michael
Purpose: To evaluate the effectiveness of cranial nerve noninvasive neuromodulation (CN-NINM) training on balance, using the PoNS 4.0 device with normal stimulation (active) versus the PoNS 4.0 device with low, perceivable stimulation that is intended to be ineffective (sham control), in subjects with a chronic balance deficit due to mild-to-moderate TBI.Title: BrainForce: A Screening Test for Concussion
Sponsor: MedStar Institute for Innovation
PI: Dromerick, Alexander; Lum, Peter; Tractenberg, Rochelle; Garmoe, William
Purpose: This study will evaluate techniques of screening individuals with suspected mild traumatic brain injury (i.e. concussion). The study will support the future development of technology that can easily & appropriately screen patients with suspected concussion either in clinical settings or in the community.
PI: Benson, Richard
Purpose: The Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial is a multicenter, randomized, controlled clinical trial of 1400 patients that will include approximately 60 enrolling sites. The study hypotheses are that treatment of hyperglycemic acute ischemic stroke patients with targeted glucose concentration (80mg/dL – 130 mg/dL) will be safe and result in improved 3 month outcome after stroke.Title: DEFUSE 3: Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke
PI: Hsia, Amie
Purpose: This is a study to evaluate the hypothesis that FDA cleared thrombectomy devices plus medical management leads to superior clinical outcomes in acute ischemic stroke patients at 90 days when compared to medical management alone in appropriately selected subjects with the Target mismatch profile and an MCA (M1 segment) or ICA occlusion who can be randomized and have endovascular treatment initiated between 6-16 hours after last seen well.Title: CREST2: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis
PI: Woo, Edward
Purpose: Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asymptomatic high-grade carotid stenosis. One trial will randomize patients in a 1:1 ratio to endarterectomy versus no endarterectomy and another will randomize patients in a 1:1 ratio to carotid stenting with embolic protection versus no stenting. Medical management will be uniform for all randomized treatment groups and will be centrally directed.
Pediatric Stroke Research
A large part of our research portfolio involves children who have had a stroke around the time of birth. For more information, please click here. For information on research participation, please click here.