The K12 Journal Club provides an opportunity for K12 scholars and rehabilitation scientists to critically discuss the latest advancements in rehabilitation science. Discussions are guided by our K12 scholars and moderated by Matt Edwardson, MD.
Dr. Edwardson is a vascular neurologist at the MedStar Georgetown stroke program. His research focuses on biomarkers of motor recovery from stroke, including molecular and neuroimaging biomarkers. He uses multi-omic methods, including transcriptomics, proteomics and lipidomics in blood plasma to identify molecules associated with stroke recovery. The long-term goal of his research is to determine the molecular underpinnings of stroke recovery in humans and use this knowledge to develop recovery-based therapeutics. His research has been supported by the Georgetown Partners in Research program, the Georgetown Center for Brain Plasticity and Recovery, and the National Institutes of Health.
For more information, or if you would like to be added to our mailing list, please contact Sunju Ahmadu, firstname.lastname@example.org, 202-877-1946.
|10/7/2020||Andrew DeMarco, PhD||Instructor of Rehabilitation Medicine, Georgetown University||1. Bates E, Wilson S, Saygin A, et al. Voxel-based lesion-symptom mapping. Nature Neuroscience. 2003; 6(5):448-450.|
2. Xu T, Jha A, Nachev P. The dimensionalities of lesion-deficit mapping. Neuropsychologia. 2018;115: 134-141.
3. DeMarco AT, Turkeltaub PE. Functional anomaly mapping reveals local and distant dysfunction caused by brain lesions. Neuroimage. 2020;15;215:116806.
|6/3/2020||Robynne Braun, MD, PhD||Assistant Professor of Neurology, University of Maryland School of Medicine; Co-Director, Stroke Rehabilitation Unit, University of Maryland Rehabilitation & Orthopaedic Institute||1. Cullen CL, Senesi M, Tang AD, et al. Low-intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain. Glia. 2019;67(8):1462-1477. |
2. McKenzie IA, Ohayon D, Li H, et al. Motor skill learning requires active central myelination. Science. 2014;346(6207):318-322.
3. Schmahmann JD, Pandya DN. Cerebral white matter–historical evolution of facts and notions concerning the organization of the fiber pathways of the brain. J Hist Neurosci. 2007;16(3):237-267.
|5/6/2020||Vibhu Sahni, PhD||Assistant Professor of Neuroscience, Brain and Mind Research Institute, Weill Cornell Medicine; Director, Laboratory for Corticospinal Specification and Circuit Repair, Burke Neurological Institute||1. Blackmore MG, Wang Z, Lerch JK, et al. Krüppel-like Factor 7 engineered for transcriptional activation promotes axon regeneration in the adult corticospinal tract. Proc Natl Acad Sci U S A. 2012;109(19):7517-7522. |
2. Bregman BS, Goldberger ME. Anatomical plasticity and sparing of function after spinal cord damage in neonatal cats. Science. 1982;217(4559):553-555.
3. Liu K, Lu Y, Lee JK, et al. PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nat Neurosci. 2010;13(9):1075-1081.
|4/1/2020||Matthew McLaughlin, MD, MS||Assistant Professor, UMKC School of Medicine||1. Wang Y, Zhao X, Lin J. Association Between CYP2C19 Loss-of-Function Allele Status and Efficacy of Clopidogrel for Risk Reduction Among Patients With Minor Stroke or Transient Ischemic Attack. JAMA. 2016 Jul 5;316(1):70-8.|
2. McLaughlin MJ, Wagner J, Shakhnovich V, Carleton B, Leeder JS. Considerations for Implementing Precision Therapeutics for Children. Clin Transl Sci. 2019 Mar;12(2):140-150.
|3/4/2020||Ania Busza, MD, PhD||Assistant Professor of Neurology, Stroke Division, University of Rochester Medical Center||1. Kim SY, Allred RP, Adkins DL, et al. Experience with the “good” limb induces aberrant synaptic plasticity in the perilesion cortex after stroke. J Neurosci. 2015;35(22):8604-8610. |
2. Michaelsen SM, Dannenbaum R, Levin MF. Task-specific training with trunk restraint on arm recovery in stroke: randomized control trial. Stroke. 2006;37(1):186-192.
|2/5/2020||Konstantinos Michmizos, PhD||Assistant Professor, Department of Computer Science, Rutgers University||1. Cassidy JM, Cramer SC. Spontaneous and Therapeutic-Induced Mechanisms of Functional Recovery After Stroke. Transl Stroke Res. 2017;8(1):33-46. |
2. Murphy TH, Corbett D. Plasticity during stroke recovery: from synapse to behaviour. Nat Rev Neurosci. 2009;10(12):861-872.
3. Rowe JB, Chan V, Ingemanson ML, Cramer SC, Wolbrecht ET, Reinkensmeyer DJ. Robotic Assistance for Training Finger Movement Using a Hebbian Model: A Randomized Controlled Trial. Neurorehabil Neural Repair. 2017;31(8):769-780.
|1/8/2020||Matt Edwardson, MD||Assistant Professor, Departments of Neurology and Rehabilitation Medicine, Georgetown University||1. Chollet F, Tardy J, Albucher JF, et al. Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial. Lancet Neurol. 2011;10(2):123-130. |
2. Edwardson MA, Wang X, Liu B, et al. Stroke Lesions in a Large Upper Limb Rehabilitation Trial Cohort Rarely Match Lesions in Common Preclinical Models. Neurorehabil Neural Repair. 2017;31(6):509-520.
3. Collaboration FT. Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial. Lancet. 2019;393(10168):265-274.
4. Nackenoff AG, Moussa-Tooks AB, McMeekin AM, Veenstra-VanderWeele J, Blakely RD. Essential Contributions of Serotonin Transporter Inhibition to the Acute and Chronic Actions of Fluoxetine and Citalopram in the SERT Met172 Mouse. Neuropsychopharmacology. 2016;41(7):1733-1741.
5. Ng KL, Gibson EM, Hubbard R, et al. Fluoxetine Maintains a State of Heightened Responsiveness to Motor Training Early After Stroke in a Mouse Model. Stroke. 2015;46(10):2951-2960.