Journal Club

The K12 Journal Club provides an opportunity for K12 scholars and rehabilitation scientists to critically discuss the latest advancements in rehabilitation science. Discussions are guided by our K12 scholars and moderated by Matt Edwardson, MD.

Dr. Edwardson is a vascular neurologist at the MedStar Georgetown stroke program. His research focuses on biomarkers of motor recovery from stroke, including molecular and neuroimaging biomarkers. He uses multi-omic methods, including transcriptomics, proteomics and lipidomics in blood plasma to identify molecules associated with stroke recovery. The long-term goal of his research is to determine the molecular underpinnings of stroke recovery in humans and use this knowledge to develop recovery-based therapeutics. His research has been supported by the Georgetown Partners in Research program, the Georgetown Center for Brain Plasticity and Recovery, and the National Institutes of Health. 

For more information, or if you would like to be added to our mailing list, please contact Sunju Ahmadu,, 202-877-1946.

6/7/2023David Cunningham, PhDAssistant Professor of Physical Medicine and Rehabilitation, Case Western Reserve University   

1. Jung P, Ziemann U. Homeostatic and nonhomeostatic modulation of learning in human motor cortex. J Neurosci. 2009 Apr 29;29(17):5597-604

2. Zhang JJ, Bai Z, Fong KNK. Priming Intermittent Theta Burst Stimulation for Hemiparetic Upper Limb After Stroke: A Randomized Controlled Trial. Stroke. 2022 Jul;53(7):2171-2181
5/3/2023Sara Hussain, PhDAssistant Professor of Kinesiology and Health Education, University of Texas at Austin1. Lafe CW, Liu F, Simpson TW, Moon CH, Collinger JL, Wittenberg GF, Urbin MA. Force oscillations underlying precision grip in humans with lesioned corticospinal tracts. Neuroimage Clin. 2023;38:103398.

2. Urbin MA, Collinger JL, Wittenberg GF. Corticospinal recruitment of spinal motor neurons in human stroke survivors. J Physiol. 2021 Sep;599(18):4357-4373.
4/25/23Davetrina Seles Gadson, PhDInstructor of Rehabilitation Medicine, Georgetown University Medical Center1. Dhand A, Luke DA, Lang CE, Lee JM. Social networks and neurological illness. Nat Rev Neurol. 2016 Oct;12(10):605-12.

2. Gadson DS, Wesley DB, van der Stelt CM, Lacey E, DeMarco AT, Snider SF, Turkeltaub PE. Aphasia severity is modulated by race and lesion size in chronic survivors: A retrospective study. J Commun Disord. 2022 Nov-Dec;100:106270.
3/2/23Andrew DeMarco, PhDInstructor of Rehabilitation Medicine, Georgetown University Medical Center1. Nudo RJ. Recovery after damage to motor cortical areas. Curr Opin Neurobiol. 1999 Dec;9(6):740-7.

2. DeMarco AT, van der Stelt C, Paul S, Dvorak E, Lacey E, Snider S, Turkeltaub PE. Absence of Perilesional Neuroplastic Recruitment in Chronic Poststroke Aphasia. Neurology. 2022 Jul 12;99(2):e119-e128.

3. Stefaniak JD, Halai AD, Lambon Ralph MA. The neural and neurocomputational bases of recovery from post-stroke aphasia. Nat Rev Neurol. 2020 Jan;16(1):43-55.
2/1/23Mackenzie Fama, PhDAssistant Professor, Department of Speech, Language, and Hearing Sciences, George Washington University1. Fama ME, Snider SF, Henderson MP, Hayward W, Friedman RB, Turkeltaub PE. The Subjective Experience of Inner Speech in Aphasia Is a Meaningful Reflection of Lexical Retrieval. J Speech Lang Hear Res. 2019 Jan 30;62(1):106-122.

2. Hayward W, Snider SF, Luta G, Friedman RB, Turkeltaub PE. Objective support for subjective reports of successful inner speech in two people with aphasia. Cogn Neuropsychol. 2016 Jul-Sep;33(5-6):299-314.
11/2/22Abhishek Jaywant, PhDAssistant Professor of Neuropsychology, Weill Cornell Medicine1. Jaywant A, Vanderlind WM, Alexopoulos GS, Fridman CB, Perlis RH, Gunning FM. Frequency and profile of objective cognitive deficits in hospitalized patients recovering from COVID-19. Neuropsychopharmacology. 2021 Dec;46(13):2235-2240.

2. Patel R, Savrides I, Cahalan C, Doulatani G, O’Dell MW, Toglia J, Jaywant A. Cognitive impairment and functional change in COVID-19 patients undergoing inpatient rehabilitation. Int J Rehabil Res. 2021 Sep 1;44(3):285-288.

3. Douaud G, Lee S, Alfaro-Almagro F, Arthofer C, Wang C, McCarthy P, Lange F, Andersson JLR, Griffanti L, Duff E, Jbabdi S, Taschler B, Keating P, Winkler AM, Collins R, Matthews PM, Allen N, Miller KL, Nichols TE, Smith SM. SARS-CoV-2 is associated with changes in brain structure in UK Biobank. Nature. 2022 Apr;604(7907):697-707.
10/5/22Shashwati Geed, PT, PhDAssistant Professor of Rehabilitation Medicine, Georgetown University Medical Center1. Lum PS, Shu L, Bochniewicz EM, Tran T, Chang LC, Barth J, Dromerick AW. Improving Accelerometry-Based Measurement of Functional Use of the Upper Extremity After Stroke: Machine Learning Versus Counts Threshold Method. Neurorehabil Neural Repair. 2020 Dec;34(12):1078-1087.

2. Waddell KJ, Strube MJ, Bailey RR, Klaesner JW, Birkenmeier RL, Dromerick AW, Lang CE. Does Task-Specific Training Improve Upper Limb Performance in Daily Life Poststroke? Neurorehabil Neural Repair. 2017 Mar;31(3):290-300.
3/2/22Davetrina Seles Gadson, PhDInstructor of Rehabilitation Medicine, Georgetown University Medical Center1. Sandel ME, Wang H, Terdiman J, Hoffman JM, Ciol MA, Sidney S, Quesenberry C, Lu Q, Chan L. Disparities in stroke rehabilitation: results of a study in an integrated health system in northern California. PM R. 2009 Jan;1(1):29-40.

2. Königsberg A, DeMarco AT, Mayer C, Wouters A, Schlemm E, Ebinger M, Cho TH, Endres M, Fiebach JB, Fiehler J, Galinovic I, Puig J, Thijs V, Lemmens R, Muir KW, Nighoghossian N, Pedraza S, Simonsen CZ, Gerloff C, Thomalla G, Cheng B. Influence of stroke infarct location on quality of life assessed in a multivariate lesion-symptom mapping study. Sci Rep. 2021 Jun 29;11(1):13490.

3. Hardy RY, Lindrooth RC, Peach RK, Ellis C. Urban-Rural Differences in Service Utilization and Costs of Care for Racial-Ethnic Groups Hospitalized With Poststroke Aphasia. Arch Phys Med Rehabil. 2019 Feb;100(2):254-260.
2/2/22Sara Pillay, PhDAssistant Professor of Neurology, Medical College of Wisconsin1. Masson-Trottier M, Sontheimer A, Durand E, Ansaldo AI. Resting-State Functional Connectivity following Phonological Component Analysis: The Combined Action of Phonology and Visual Orthographic Cues. Brain Sci. 2021 Nov 2;11(11):1458.

2. Hartwigsen G, Stockert A, Charpentier L, Wawrzyniak M, Klingbeil J, Wrede K, Obrig H, Saur D. Short-term modulation of the lesioned language network. Elife. 2020 Mar 17;9:e54277.

3. Wilson SM, Schneck SM. Neuroplasticity in post-stroke aphasia: A systematic review and meta-analysis of functional imaging studies of reorganization of language processing. Neurobiol Lang (Camb). 2021;2(1):22-82.
1/5/22Shashwati Geed, PT, PhDAssistant Professor of Rehabilitation Medicine, Georgetown University Medical Center1. Biernaskie J, Chernenko G, Corbett D. Efficacy of rehabilitative experience declines with time after focal ischemic brain injury. J Neurosci. 2004 Feb 4;24(5):1245-54.

2. Biernaskie J, Corbett D. Enriched rehabilitative training promotes improved forelimb motor function and enhanced dendritic growth after focal ischemic injury. J Neurosci. 2001 Jul 15;21(14):5272-80.

3. Dromerick AW, Geed S, Barth J, Brady K, Giannetti ML, Mitchell A, Edwardson MA, Tan MT, Zhou Y, Newport EL, Edwards DF. Critical Period After Stroke Study (CPASS): A phase II clinical trial testing an optimal time for motor recovery after stroke in humans. Proc Natl Acad Sci U S A. 2021 Sep 28;118(39):e2026676118.
12/1/21David Cunningham, PhDAssistant Professor of Physical Medicine and Rehabilitation Medicine, Case Western University School of Medicine1. Cattaneo L, Voss M, Brochier T, Prabhu G, Wolpert DM, Lemon RN. A cortico-cortical mechanism mediating object-driven grasp in humans. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):898-903.

2. Long J, Federico P, Perez MA. A novel cortical target to enhance hand motor output in humans with spinal cord injury. Brain. 2017 Jun 1;140(6):1619-1632. 

3. Thabit MN, Ueki Y, Koganemaru S, Fawi G, Fukuyama H, Mima T. Movement-related cortical stimulation can induce human motor plasticity. J Neurosci. 2010 Aug 25;30(34):11529-36.
6/2/21Oluwole Awosika, MDAssistant Professor of Neurology and Rehabilitation Medicine, University of Cincinnati1. Rose DK, DeMark L, Fox EJ, Clark DJ, Wludyka P. A Backward Walking Training Program to Improve Balance and Mobility in Acute Stroke: A Pilot Randomized Controlled Trial. J Neurol Phys Ther. 2018 Jan;42(1):12-21.

2. Mitsutake T, Sakamoto M, Ueta K, Oka S, Horikawa E. Effects of vestibular rehabilitation on gait performance in poststroke patients: a pilot randomized controlled trial. Int J Rehabil Res. 2017 Sep;40(3):240-245.

3. Lechanoine F, Jacquesson T, Beaujoin J, Serres B, Mohammadi M, Planty-Bonjour A, Andersson F, Poupon F, Poupon C, Destrieux C. WIKIBrainStem: An online atlas to manually segment the human brainstem at the mesoscopic scale from ultrahigh field MRI. Neuroimage. 2021 Apr 18;236:118080.
5/5/21Shashwati Geed, PhDAssistant Professor of Rehabilitation Medicine, Georgetown University Medical Center1. Miller LC, Dewald JP. Involuntary paretic wrist/finger flexion forces and EMG increase with shoulder abduction load in individuals with chronic stroke. Clin Neurophysiol. 2012 Jun;123(6):1216-25.

2. Geed S, Grainger M, Harris-Love ML, Lum PS, Dromerick AW. Shoulder position and handedness differentially affect excitability and intracortical inhibition of hand muscles. Exp Brain Res. 2021 Mar 9.
3/3/2021Matthew Mclaughlin, MDAssistant Professor of Rehabilitation Medicine, University of Missouri Kansas-City School of Medicine1. Yablon SA, Brin MF, VanDenburgh AM, Zhou J, Garabedian-Ruffalo SM, Abu-Shakra S, Beddingfield FC 3rd. Dose response with onabotulinumtoxinA for post-stroke spasticity: a pooled data analysis. Mov Disord. 2011 Feb 1;26(2):209-15.

2. Hastings-Ison T, Blackburn C, Rawicki B, Fahey M, Simpson P, Baker R, Graham K. Injection frequency of botulinum toxin A for spastic equinus: a randomized clinical trial. Dev Med Child Neurol. 2016 Jul;58(7):750-7.

2/3/2021Konstantinos Michmizos, PhDAssistant Professor of Computer Science, Rutgers University1. Schirrmeister, R,
Springenberg, J,
Fiederer, L, et al. Deep Learning With Convolutional Neural
Networks for EEG Decoding and Visualization. Human Brain Mapping. 2017′; 38(11): 5391-5420.

2. Tacchino G, Gandolla M, Coelli S, et al. EEG Analysis During Active and Assisted Repetitive Movements: Evidence for Differences in Neural Engagement. IEEE Trans Neural Syst Rehabil Eng. 2017 Jun;25(6):761-771. 

3. Lotze M, Braun C, Birbaumer N, Anders S, Cohen LG. Motor learning elicited by voluntary drive. Brain. 2003 Apr;126(Pt 4):866-72.
12/2/2020Abhishek Jaywant, PhDAssistant Professor of Neuropsychology, Departments of Psychiatry & Rehabilitation Medicine1. Sporns, Olaf, Betzel, Richard F. Modular brain networks. Annual Review of Psychology. 2016; 67: 613-640.

2. Siegel J, Seitzman B, Ramsey L, et al. Re-emergence of modular brain networks in stroke recovery. Cortex. 2018; 101:44-59.

3. Arnemann K, Chen A, Novakovic-Agopian T, et al. Functional brain network modularity predicts response to cognitive training after brain injury. Neurology. 2015 Apr 14;84(15):1568-74. 
10/7/2020Andrew DeMarco, PhDInstructor of Rehabilitation Medicine, Georgetown University 1. Bates E, Wilson S, Saygin A, et al. Voxel-based lesion-symptom mapping. Nature Neuroscience. 2003; 6(5):448-450.

2. Xu T, Jha A, Nachev P. The dimensionalities of lesion-deficit mapping. Neuropsychologia. 2018;115: 134-141.

3. DeMarco AT, Turkeltaub PE. Functional anomaly mapping reveals local and distant dysfunction caused by brain lesions. Neuroimage. 2020;15;215:116806. 
6/3/2020Robynne Braun, MD, PhDAssistant Professor of Neurology, University of Maryland School of Medicine; Co-Director, Stroke Rehabilitation Unit, University of Maryland Rehabilitation & Orthopaedic Institute1. Cullen CL, Senesi M, Tang AD, et al. Low-intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain. Glia. 2019;67(8):1462-1477.  

2. McKenzie IA, Ohayon D, Li H, et al. Motor skill learning requires active central myelination. Science. 2014;346(6207):318-322.

3. Schmahmann JD, Pandya DN. Cerebral white matter–historical evolution of facts and notions concerning the organization of the fiber pathways of the brain. J Hist Neurosci. 2007;16(3):237-267.
5/6/2020Vibhu Sahni, PhDAssistant Professor of Neuroscience, Brain and Mind Research Institute, Weill Cornell Medicine; Director, Laboratory for Corticospinal Specification and Circuit Repair, Burke Neurological Institute1. Blackmore MG, Wang Z, Lerch JK, et al. Krüppel-like Factor 7 engineered for transcriptional activation promotes axon regeneration in the adult corticospinal tract. Proc Natl Acad Sci U S A. 2012;109(19):7517-7522.  

2. Bregman BS, Goldberger ME. Anatomical plasticity and sparing of function after spinal cord damage in neonatal cats. Science. 1982;217(4559):553-555.

3. Liu K, Lu Y, Lee JK, et al. PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nat Neurosci. 2010;13(9):1075-1081.
4/1/2020Matthew McLaughlin, MD, MSAssistant Professor, UMKC School of Medicine1. Wang Y, Zhao X, Lin J. Association Between CYP2C19 Loss-of-Function Allele Status and Efficacy of Clopidogrel for Risk Reduction Among Patients With Minor Stroke or Transient Ischemic Attack. JAMA. 2016 Jul 5;316(1):70-8.

2. McLaughlin MJ, Wagner J, Shakhnovich V, Carleton B, Leeder JS. Considerations for Implementing Precision Therapeutics for Children. Clin Transl Sci. 2019 Mar;12(2):140-150.

3/4/2020Ania Busza, MD, PhDAssistant Professor of Neurology, Stroke Division, University of Rochester Medical Center1. Kim SY, Allred RP, Adkins DL, et al. Experience with the “good” limb induces aberrant synaptic plasticity in the perilesion cortex after stroke. J Neurosci. 2015;35(22):8604-8610.  

2. Michaelsen SM, Dannenbaum R, Levin MF. Task-specific training with trunk restraint on arm recovery in stroke: randomized control trial. Stroke. 2006;37(1):186-192.
2/5/2020Konstantinos Michmizos, PhDAssistant Professor, Department of Computer Science, Rutgers University 1. Cassidy JM, Cramer SC. Spontaneous and Therapeutic-Induced Mechanisms of Functional Recovery After Stroke. Transl Stroke Res. 2017;8(1):33-46.  

2. Murphy TH, Corbett D. Plasticity during stroke recovery: from synapse to behaviour. Nat Rev Neurosci. 2009;10(12):861-872.

3. Rowe JB, Chan V, Ingemanson ML, Cramer SC, Wolbrecht ET, Reinkensmeyer DJ. Robotic Assistance for Training Finger Movement Using a Hebbian Model: A Randomized Controlled Trial. Neurorehabil Neural Repair. 2017;31(8):769-780.
1/8/2020Matt Edwardson, MDAssistant Professor, Departments of Neurology and Rehabilitation Medicine, Georgetown University1. Chollet F, Tardy J, Albucher JF, et al. Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial. Lancet Neurol. 2011;10(2):123-130.  

2. Edwardson MA, Wang X, Liu B, et al. Stroke Lesions in a Large Upper Limb Rehabilitation Trial Cohort Rarely Match Lesions in Common Preclinical Models. Neurorehabil Neural Repair. 2017;31(6):509-520.

3. Collaboration FT. Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial. Lancet. 2019;393(10168):265-274.

4. Nackenoff AG, Moussa-Tooks AB, McMeekin AM, Veenstra-VanderWeele J, Blakely RD. Essential Contributions of Serotonin Transporter Inhibition to the Acute and Chronic Actions of Fluoxetine and Citalopram in the SERT Met172 Mouse. Neuropsychopharmacology. 2016;41(7):1733-1741.

5. Ng KL, Gibson EM, Hubbard R, et al. Fluoxetine Maintains a State of Heightened Responsiveness to Motor Training Early After Stroke in a Mouse Model. Stroke. 2015;46(10):2951-2960.