The K12 Journal Club provides an opportunity for K12 scholars and rehabilitation scientists to critically discuss the latest advancements in rehabilitation science. Discussions are guided by our K12 scholars and moderated by Matt Edwardson, MD.
Dr. Edwardson is a vascular neurologist at the MedStar Georgetown stroke program. His research focuses on biomarkers of motor recovery from stroke, including molecular and neuroimaging biomarkers. He uses multi-omic methods, including transcriptomics, proteomics and lipidomics in blood plasma to identify molecules associated with stroke recovery. The long-term goal of his research is to determine the molecular underpinnings of stroke recovery in humans and use this knowledge to develop recovery-based therapeutics. His research has been supported by the Georgetown Partners in Research program, the Georgetown Center for Brain Plasticity and Recovery, and the National Institutes of Health.
For more information, or if you would like to be added to our mailing list, please contact Sunju Ahmadu, firstname.lastname@example.org, 202-877-1946.
|10/5/22||Shashwati Geed, PT, PhD||Assistant Professor of Rehabilitation Medicine, Georgetown University Medical Center||1. Lum PS, Shu L, Bochniewicz EM, Tran T, Chang LC, Barth J, Dromerick AW. Improving Accelerometry-Based Measurement of Functional Use of the Upper Extremity After Stroke: Machine Learning Versus Counts Threshold Method. Neurorehabil Neural Repair. 2020 Dec;34(12):1078-1087.|
2. Waddell KJ, Strube MJ, Bailey RR, Klaesner JW, Birkenmeier RL, Dromerick AW, Lang CE. Does Task-Specific Training Improve Upper Limb Performance in Daily Life Poststroke? Neurorehabil Neural Repair. 2017 Mar;31(3):290-300.
|3/2/22||Davetrina Seles Gadson, PhD||Instructor of Rehabilitation Medicine, Georgetown University Medical Center||1. Sandel ME, Wang H, Terdiman J, Hoffman JM, Ciol MA, Sidney S, Quesenberry C, Lu Q, Chan L. Disparities in stroke rehabilitation: results of a study in an integrated health system in northern California. PM R. 2009 Jan;1(1):29-40.|
2. Königsberg A, DeMarco AT, Mayer C, Wouters A, Schlemm E, Ebinger M, Cho TH, Endres M, Fiebach JB, Fiehler J, Galinovic I, Puig J, Thijs V, Lemmens R, Muir KW, Nighoghossian N, Pedraza S, Simonsen CZ, Gerloff C, Thomalla G, Cheng B. Influence of stroke infarct location on quality of life assessed in a multivariate lesion-symptom mapping study. Sci Rep. 2021 Jun 29;11(1):13490.
3. Hardy RY, Lindrooth RC, Peach RK, Ellis C. Urban-Rural Differences in Service Utilization and Costs of Care for Racial-Ethnic Groups Hospitalized With Poststroke Aphasia. Arch Phys Med Rehabil. 2019 Feb;100(2):254-260.
|2/2/22||Sara Pillay, PhD||Assistant Professor of Neurology, Medical College of Wisconsin||1. Masson-Trottier M, Sontheimer A, Durand E, Ansaldo AI. Resting-State Functional Connectivity following Phonological Component Analysis: The Combined Action of Phonology and Visual Orthographic Cues. Brain Sci. 2021 Nov 2;11(11):1458.|
2. Hartwigsen G, Stockert A, Charpentier L, Wawrzyniak M, Klingbeil J, Wrede K, Obrig H, Saur D. Short-term modulation of the lesioned language network. Elife. 2020 Mar 17;9:e54277.
3. Wilson SM, Schneck SM. Neuroplasticity in post-stroke aphasia: A systematic review and meta-analysis of functional imaging studies of reorganization of language processing. Neurobiol Lang (Camb). 2021;2(1):22-82.
|1/5/22||Shashwati Geed, PT, PhD||Assistant Professor of Rehabilitation Medicine, Georgetown University Medical Center||1. Biernaskie J, Chernenko G, Corbett D. Efficacy of rehabilitative experience declines with time after focal ischemic brain injury. J Neurosci. 2004 Feb 4;24(5):1245-54.|
2. Biernaskie J, Corbett D. Enriched rehabilitative training promotes improved forelimb motor function and enhanced dendritic growth after focal ischemic injury. J Neurosci. 2001 Jul 15;21(14):5272-80.
3. Dromerick AW, Geed S, Barth J, Brady K, Giannetti ML, Mitchell A, Edwardson MA, Tan MT, Zhou Y, Newport EL, Edwards DF. Critical Period After Stroke Study (CPASS): A phase II clinical trial testing an optimal time for motor recovery after stroke in humans. Proc Natl Acad Sci U S A. 2021 Sep 28;118(39):e2026676118.
|12/1/21||David Cunningham, PhD||Assistant Professor of Physical Medicine and Rehabilitation Medicine, Case Western University School of Medicine||1. Cattaneo L, Voss M, Brochier T, Prabhu G, Wolpert DM, Lemon RN. A cortico-cortical mechanism mediating object-driven grasp in humans. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):898-903. |
2. Long J, Federico P, Perez MA. A novel cortical target to enhance hand motor output in humans with spinal cord injury. Brain. 2017 Jun 1;140(6):1619-1632.
3. Thabit MN, Ueki Y, Koganemaru S, Fawi G, Fukuyama H, Mima T. Movement-related cortical stimulation can induce human motor plasticity. J Neurosci. 2010 Aug 25;30(34):11529-36.
|6/2/21||Oluwole Awosika, MD||Assistant Professor of Neurology and Rehabilitation Medicine, University of Cincinnati||1. Rose DK, DeMark L, Fox EJ, Clark DJ, Wludyka P. A Backward Walking Training Program to Improve Balance and Mobility in Acute Stroke: A Pilot Randomized Controlled Trial. J Neurol Phys Ther. 2018 Jan;42(1):12-21. |
2. Mitsutake T, Sakamoto M, Ueta K, Oka S, Horikawa E. Effects of vestibular rehabilitation on gait performance in poststroke patients: a pilot randomized controlled trial. Int J Rehabil Res. 2017 Sep;40(3):240-245.
3. Lechanoine F, Jacquesson T, Beaujoin J, Serres B, Mohammadi M, Planty-Bonjour A, Andersson F, Poupon F, Poupon C, Destrieux C. WIKIBrainStem: An online atlas to manually segment the human brainstem at the mesoscopic scale from ultrahigh field MRI. Neuroimage. 2021 Apr 18;236:118080.
|5/5/21||Shashwati Geed, PhD||Assistant Professor of Rehabilitation Medicine, Georgetown University Medical Center||1. Miller LC, Dewald JP. Involuntary paretic wrist/finger flexion forces and EMG increase with shoulder abduction load in individuals with chronic stroke. Clin Neurophysiol. 2012 Jun;123(6):1216-25. |
2. Geed S, Grainger M, Harris-Love ML, Lum PS, Dromerick AW. Shoulder position and handedness differentially affect excitability and intracortical inhibition of hand muscles. Exp Brain Res. 2021 Mar 9.
|3/3/2021||Matthew Mclaughlin, MD||Assistant Professor of Rehabilitation Medicine, University of Missouri Kansas-City School of Medicine||1. Yablon SA, Brin MF, VanDenburgh AM, Zhou J, Garabedian-Ruffalo SM, Abu-Shakra S, Beddingfield FC 3rd. Dose response with onabotulinumtoxinA for post-stroke spasticity: a pooled data analysis. Mov Disord. 2011 Feb 1;26(2):209-15. |
2. Hastings-Ison T, Blackburn C, Rawicki B, Fahey M, Simpson P, Baker R, Graham K. Injection frequency of botulinum toxin A for spastic equinus: a randomized clinical trial. Dev Med Child Neurol. 2016 Jul;58(7):750-7.
|2/3/2021||Konstantinos Michmizos, PhD||Assistant Professor of Computer Science, Rutgers University||1. Schirrmeister, R,|
Fiederer, L, et al. Deep Learning With Convolutional Neural
Networks for EEG Decoding and Visualization. Human Brain Mapping. 2017′; 38(11): 5391-5420.
2. Tacchino G, Gandolla M, Coelli S, et al. EEG Analysis During Active and Assisted Repetitive Movements: Evidence for Differences in Neural Engagement. IEEE Trans Neural Syst Rehabil Eng. 2017 Jun;25(6):761-771.
3. Lotze M, Braun C, Birbaumer N, Anders S, Cohen LG. Motor learning elicited by voluntary drive. Brain. 2003 Apr;126(Pt 4):866-72.
|12/2/2020||Abhishek Jaywant, PhD||Assistant Professor of Neuropsychology, Departments of Psychiatry & Rehabilitation Medicine||1. Sporns, Olaf, Betzel, Richard F. Modular brain networks. Annual Review of Psychology. 2016; 67: 613-640.|
2. Siegel J, Seitzman B, Ramsey L, et al. Re-emergence of modular brain networks in stroke recovery. Cortex. 2018; 101:44-59.
3. Arnemann K, Chen A, Novakovic-Agopian T, et al. Functional brain network modularity predicts response to cognitive training after brain injury. Neurology. 2015 Apr 14;84(15):1568-74.
|10/7/2020||Andrew DeMarco, PhD||Instructor of Rehabilitation Medicine, Georgetown University||1. Bates E, Wilson S, Saygin A, et al. Voxel-based lesion-symptom mapping. Nature Neuroscience. 2003; 6(5):448-450.|
2. Xu T, Jha A, Nachev P. The dimensionalities of lesion-deficit mapping. Neuropsychologia. 2018;115: 134-141.
3. DeMarco AT, Turkeltaub PE. Functional anomaly mapping reveals local and distant dysfunction caused by brain lesions. Neuroimage. 2020;15;215:116806.
|6/3/2020||Robynne Braun, MD, PhD||Assistant Professor of Neurology, University of Maryland School of Medicine; Co-Director, Stroke Rehabilitation Unit, University of Maryland Rehabilitation & Orthopaedic Institute||1. Cullen CL, Senesi M, Tang AD, et al. Low-intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain. Glia. 2019;67(8):1462-1477. |
2. McKenzie IA, Ohayon D, Li H, et al. Motor skill learning requires active central myelination. Science. 2014;346(6207):318-322.
3. Schmahmann JD, Pandya DN. Cerebral white matter–historical evolution of facts and notions concerning the organization of the fiber pathways of the brain. J Hist Neurosci. 2007;16(3):237-267.
|5/6/2020||Vibhu Sahni, PhD||Assistant Professor of Neuroscience, Brain and Mind Research Institute, Weill Cornell Medicine; Director, Laboratory for Corticospinal Specification and Circuit Repair, Burke Neurological Institute||1. Blackmore MG, Wang Z, Lerch JK, et al. Krüppel-like Factor 7 engineered for transcriptional activation promotes axon regeneration in the adult corticospinal tract. Proc Natl Acad Sci U S A. 2012;109(19):7517-7522. |
2. Bregman BS, Goldberger ME. Anatomical plasticity and sparing of function after spinal cord damage in neonatal cats. Science. 1982;217(4559):553-555.
3. Liu K, Lu Y, Lee JK, et al. PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nat Neurosci. 2010;13(9):1075-1081.
|4/1/2020||Matthew McLaughlin, MD, MS||Assistant Professor, UMKC School of Medicine||1. Wang Y, Zhao X, Lin J. Association Between CYP2C19 Loss-of-Function Allele Status and Efficacy of Clopidogrel for Risk Reduction Among Patients With Minor Stroke or Transient Ischemic Attack. JAMA. 2016 Jul 5;316(1):70-8.|
2. McLaughlin MJ, Wagner J, Shakhnovich V, Carleton B, Leeder JS. Considerations for Implementing Precision Therapeutics for Children. Clin Transl Sci. 2019 Mar;12(2):140-150.
|3/4/2020||Ania Busza, MD, PhD||Assistant Professor of Neurology, Stroke Division, University of Rochester Medical Center||1. Kim SY, Allred RP, Adkins DL, et al. Experience with the “good” limb induces aberrant synaptic plasticity in the perilesion cortex after stroke. J Neurosci. 2015;35(22):8604-8610. |
2. Michaelsen SM, Dannenbaum R, Levin MF. Task-specific training with trunk restraint on arm recovery in stroke: randomized control trial. Stroke. 2006;37(1):186-192.
|2/5/2020||Konstantinos Michmizos, PhD||Assistant Professor, Department of Computer Science, Rutgers University||1. Cassidy JM, Cramer SC. Spontaneous and Therapeutic-Induced Mechanisms of Functional Recovery After Stroke. Transl Stroke Res. 2017;8(1):33-46. |
2. Murphy TH, Corbett D. Plasticity during stroke recovery: from synapse to behaviour. Nat Rev Neurosci. 2009;10(12):861-872.
3. Rowe JB, Chan V, Ingemanson ML, Cramer SC, Wolbrecht ET, Reinkensmeyer DJ. Robotic Assistance for Training Finger Movement Using a Hebbian Model: A Randomized Controlled Trial. Neurorehabil Neural Repair. 2017;31(8):769-780.
|1/8/2020||Matt Edwardson, MD||Assistant Professor, Departments of Neurology and Rehabilitation Medicine, Georgetown University||1. Chollet F, Tardy J, Albucher JF, et al. Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial. Lancet Neurol. 2011;10(2):123-130. |
2. Edwardson MA, Wang X, Liu B, et al. Stroke Lesions in a Large Upper Limb Rehabilitation Trial Cohort Rarely Match Lesions in Common Preclinical Models. Neurorehabil Neural Repair. 2017;31(6):509-520.
3. Collaboration FT. Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial. Lancet. 2019;393(10168):265-274.
4. Nackenoff AG, Moussa-Tooks AB, McMeekin AM, Veenstra-VanderWeele J, Blakely RD. Essential Contributions of Serotonin Transporter Inhibition to the Acute and Chronic Actions of Fluoxetine and Citalopram in the SERT Met172 Mouse. Neuropsychopharmacology. 2016;41(7):1733-1741.
5. Ng KL, Gibson EM, Hubbard R, et al. Fluoxetine Maintains a State of Heightened Responsiveness to Motor Training Early After Stroke in a Mouse Model. Stroke. 2015;46(10):2951-2960.